Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Let’s never spend our New Year apart.让我们永不独享新年。
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Tuesday’s event at Apple’s new Cupertino headquarters is expected to reveal its much-anticipated 10th-anniversary iPhone, offering significant upgrades to the smartphone’s display, camera and overall design.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
5. 弗莱德·赫什三人组(Fred Hersch Trio)，《漂浮》(Floating)， Palmetto。赫什目前的钢琴三人组由约翰·艾伯特(John Hébert)担任贝斯，埃里克·麦克菲森(Eric McPherson)担任鼓手，他们有着精确的优雅。这张专辑的结构如同一场夜间俱乐部演出，包括若干重新编配的标准曲，以及几首强劲而充满情感的原创曲，有着强大的表现力。
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
While British schools moved up two places on average, French schools, the largest group from any one country, fell one place on average. EMLyon Business School dropped outside the MBA ranking and lost 15 places overall, while Edhec Business School failed to make it into the Executive MBA ranking and lost eight places overall as a result.
While heavily dominated by French and English schools, accounting for 44 per cent of the table, the ranking is more diverse than ever with schools from 25 countries.
Susan Chan, head of iShares Asia-Pacific at BlackRock, says ETFs are more popular among institutional investors in the region.
Trends and targets in antiviral phototherapy
He added that “almost every major Korean company, including Hyundai Motor and AmorePacific, relies heavily on Chinese sales”.
Price growth in top cities was slower, however, with Beijing, for instance, reporting a rise of only 0.5 per cent from the previous month, compared to 4.9 per cent in September.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Despite such arguments from a handful of scientists, the vast majority of those who study the climate say the earth is in a long-term warming trend that is profoundly threatening and caused almost entirely by human activity.
ACE2 as a potential therapeutic target for pandemic COVID-19
May the beauty and joy of New Year remain with you throughout the new year!愿新春美景与欢乐常伴随你！
Diagnostic technologies for COVID-19: a review
James Bond Themes 5. "Live and Let Die" by Paul McCartney and Wings
"No one really knows how (end times) would look and how God would bring it about," Cox said.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Google's top 10 searches for 2017–U.S.
Most Catholics (60 percent) and white non-evangelical Protestants (65 percent) say they believe disasters like hurricanes and floods are the result of climate change.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Télécom Business School in France and Prague’s University of Economics have the most gender-balanced faculty, with exactly 50 per cent women, while Switzerland’s University of Zurich is the least balanced, with only 9 per cent. Switzerland’s IMD has the most international faculty, with 94 per cent of them from overseas, while faculty at Politecnico di Milano School of Management are all Italian.
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Last year, the Education Ministry issued a booklet warning Korean high school students of 'plastic surgery syndrome', citing Michael Jackson and a local woman whose addiction to plastic surgery left her with a grotesquely swollen face.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
在出售给Facebook前，WhatsApp一直特别反对植入广告。该公司首席执行官让o库姆在自己桌上一直贴着联合创始人布莱恩o阿克顿留下的一张便条，随时提醒自己牢记公司的核心价值观：“不要广告！不要游戏！不要宣传噱头！”这样一来，短信应用只好想出别的创意。比如Tango就在用户的短信“收件箱”里插入广告。中国互联网巨头腾讯公司旗下的短信应用——微信，则通过游戏、贴纸（类似于表情符号）和移动购物等方式谋取赚钱之道。Kik则提供一种被一些人称为“聊天广告”的功能，用户通过它能和幽默网站Funny or Die及电影信息网站Moviefone这类品牌运营的聊天程序进行交谈。
Antiviral drug discovery: broad-spectrum drugs from nature
CONTACT: Staci Donegan and Peter Westley, Celia Dunn Sotheby’s International Realty, (912) 247-2052 / (912) 660-5169; celiadunnsir.com
Influenza neuraminidase: A druggable target for natural products
2.You Never Have a Day When You Wake Up Excited To Go To Work
RSPCA inspectors found 13 dead cats and an emaciated survivor when they raided the property in Adelaide, South Australia, in September 2015.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
PRICE PER SQUARE FOOT: $310
Democratic frontrunner Hillary Clinton says that if she's elected president, at least half of her Cabinet will be women.
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
都柏林大学学院(UCD)迈克尔?斯墨菲特商业研究生院(Michael Smurfit Graduate School of Business)的总体进步最大，排名攀升21位至第48名。北京大学(Peking University)光华管理学院(Guanghua School of Management)重回排行榜第38名，去年该院因学员调查反馈率低而未上榜。
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
adj. 投影的，投射 v. 投射（project的过去
《初来乍到》(Fresh off the Boat)，ABC，2月4日播出。这部喜剧是根据大厨与美食、旅游真人秀主持人黄颐铭的回忆录改编的，讲述20世纪90年代中期的佛罗里达，一个华裔美国家庭克服文化冲突，努力适应美国生活的故事。哈德逊·杨(Hudson Yang)饰演迷恋嘻哈乐的11岁男孩艾迪，在《采访》(The Interview)中饰演金正恩的兰道尔·朴(Randall Park)饰演他的父亲，一位郊区牛排餐厅骄傲的店主。
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
"Hiring a veteran can be one of the best decisions any of us can make, and Wal-Mart is proud that we have hired more than 26,000 since we announced our Welcome Home Commitment on Memorial Day," Simon told Fortune. "Veterans have a strong record of performance under pressure and passion for service, which makes our pledge to hire, learn from, and support them easy."
Have some respect for those who are promoting your work and hosting you to remove the gum before the interview begins.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Local-level work experience will advantageous for applicants, with personnel with more than two years of experience at this level given some advantage.
Inhibition of SARS coronavirus helicase by bismuth complexes
But shipments to other destinations fared far worse, particularly those to re-exporter Hong Kong, which saw the dollar value of exports from China contract 26.3 per cent year on year to $33.84bn. Shipments to EU countries also fell 4.7 per cent to $33.5bn, while those to Japan dropped 5.5 per cent to $11.27bn.
As the new iPhone continues to smash its own launch records, Mr Cook has unveiled products such as Apple Watch and Apple Pay that take the iPhone maker into the realms of fashion and finance, recapturing a spirit of innovation that many feared had died with Jobs. In the process, Apple’s valuation this year has grown by almost as much as Google’s entire market capitalisation.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
The contiguous United States set a temperature record in 2012, a year of scorching heat waves and drought. But, mostly because of the unusual chill in the East, 2014 was only the 34th warmest year on record for the lower 48 states.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Stand: Apple CEO Tim Cook fought for workplace protection for the LGBT community
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
In the most significant change in methodology since this ranking was first published in 2005, the FT now collects information about alumni’s first jobs after graduation. These data are used in conjunction with information about their current jobs, three years later. This allows the FT to calculate their salary increase since graduation — a new ranking criterion — as well as their career progress (see methodology).
第一次出现在人体内。禽类可能是病毒来源。Appeared for the first time in humans. It caused illness in two children in Hong Kong, with poultry being the probable source.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
A Times reporter, Denise Grady, went inside an operating room to observe an experimental technique to treat severe spina bifida in a 24-week-old fetus. The doctors performing the surgery hope it will result in superior outcomes for children born with the disorder. Their first 28 surgeries have seen good results so far. Jan. 14 is the due date for the mother who was the subject of the article.
More recently, however, General Motors made a self-driving car in 1958 that adjusted its steering wheel based on the alternating currents given off by a wire placed inside the road. While the vehicle did actually drive itself, it does not qualify as the first autonomous vehicle because it depended on wires placed inside the ground. The world's first autonomous vehicle was made by S. Tsugawa and several of his colleagues at Japan's Tsukuba Mechanical Engineering Laboratory. However, German engineer Ernst Dickinson is regarded as the pioneer of the autonomous car. In 1987, he developed the VaMoRs which was capable of traveling more than 90 kilometers per hour (55 mph) for about 20 kilometers (12 mi). Seven years later, he made the VaMP, which could recognize road signs, know its own position in a lane, detect other vehicles, and even decide when to change lanes. And a year after that, he and his team made another autonomous vehicle which traveled from Germany to Denmark. The vehicle had a maximum speed of 180 kilometers per hour (111 mph) and was controlled by a human for about 5 percent of the journey.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
7. Amy Adams - $13.5 million
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Welcome, and before we begin – please accept our apologies. Your four-hour nightmare wait at passport control should not be taken as a symptom of Britain's contempt for foreigners. It is merely a symptom of a woeful lack of spending on a key aspect of travel infrastructure in the run-up to a hugely important event. In other words, it's the government that hates you. Don't worry, they hate us too.
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Influenced by the current economic situation, and resource relocation in China's financial market, the banking industry is away from the high-speed growth period, the expert added.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Vegetable price growth more than doubled to 13 per cent year on year, helping push food inflation to 3 per cent, up from 2.7 per cent in September.
Thirty-six Chinese brands have made it onto the list this year. Among them, eight are in the top 100, including the State Grid Corporation of China (36), the Industrial and Commercial Bank of China (ICBC) (40), Tencent (43), China Central Television (CCTV) (62), Haier (76), China Mobile (79), Huawei (81) and Lenovo (90).
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Tuesday’s event at Apple’s new Cupertino headquarters is expected to reveal its much-anticipated 10th-anniversary iPhone, offering significant upgrades to the smartphone’s display, camera and overall design.
Zheng Gang, a member of the CPPCC National Committee and deputy mayor of Danzhou city, Hainan province.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
It is a timely warning. His findings, he writes, “point to a heightened risk of emerging market crises in the coming years as the Fed continues to normalise interest rates”.
Elsewhere, Dua Lipa, who was up for three gongs, took home the Best New Artist award. While Harry Styles might have a reputation for being one of the most stylish members of One Direction, the Sign of the Times singer had his crown stolen by surprise MTV EMAs newcomer and former band mate, ZAYN.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
SAN JUAN, Puerto Rico (AP) — Puerto Rico’s new governor was sworn in Monday as the U.S. territory prepares for what many believe will be new austerity measures and a renewed push for statehood to haul the island out of a deep economic crisis.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
当晚的最高价来自唯一的一位欧洲电话出价人。此人以910万英镑购得约翰·康斯特布尔(John Constable)令人钦佩但很难让人喜爱的1824年纵向风景画《水闸》(The Lock)的1825年缩小版，这幅画从1855年起一直由一个英国家族私藏。
Female and male participants typically have similar profiles at the start of their EMBA.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
We learned about a warehouse that is like a mausoleum for endangered species.
It’s wall-to-wall pure pop heaven, crackling with originality and dark humor, teeming with action sequences so perfectly timed and executed you almost want to run out of the theater on the spot so you can call a friend and rave about it — but you wouldn’t dare leave your seat because you wouldn’t want to miss a frame of this brilliant, pulse-quickening gem.
节目9 相声《这事儿不赖我》，曹云金 刘云天
A modular microarray imaging system for highly specific COVID-19 antibody testing
By investing deep in the industrial fabric of the country, from the coastal cities of Tianjin and Shanghai to the new industrial frontiers of the Western provinces of Shaanxi and Sichuan, from the processing of rare metals to the manufacturing and assembly of complex aircraft parts, China is adding substance to formand showing the world that, as far as its commercial aerospace achievements are concerned, the best is yet to come.
“谁来支付由此产生的成本呢？”纽约合作公寓和共管公寓委员会(Council of New York Cooperatives and Condominiums)的主席马克·J·卢森堡(Marc J. Luxemburg)表示，“这会给许多楼盘带来真真切切的成本。”
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Song “Happiness” (Mao A’Min)
I am calling this the Wan Long prize, after the Chinese meat magnate who once uttered the clearest sentence ever spoken by a CEO: “What I do is kill pigs and sell meat.” Mr Wan will surely approve of my winner, a BNSF railway executive who told a conference: “We move stuff from one place to another.”
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
With Westbrook playing such a hands-on, high-usage role and Victor Oladipo already locked in on a high-dollar extension, Payne needed to prove he could be an off-ball threat or a lead guard on the second unit.
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Other Chinese companies that filed a large number of patents included ZTE, Alibaba, Xiaomi, BYD and Haier, all of which are rapidly expanding into Europe.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Overall, St Gallen’s alumni report a 95 per cent satisfaction level, 2 percentage points more than the alumni from London Business School and WHU Beisheim.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
"It's not sustainable growth because they're not being rented out and they're pricing people in the local market out of buying."
A facile assay for rapid detection of COVID-19 antibodies
Inarritu said: "I forgot to thank all the native Americans who made this film possible. I cannot say how surprised I am and how proud I am to have survived this film with all these fellows."
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
The pair stand on opposite sides backstage and memorize the winners to avoid having to write them down and have revealed in the past how they carry out rigorous checks to ensure they have stuffed the envelopes correctly. It is believed Ruiz and Cullinan are ordered to destroy the duplicate cards as the presentation goes on, so by the time Best Picture is awarded, the only envelopes left are the two for Best Picture.
Though Hand was British Petroleum's SVP of Global Brand, Marketing and Innovation, for several years, she's on a much more environmentally friendly mission today. Project Frog aims to revamp the construction industry with simple-to-build spaces (they takes days, rather than months to construct) that consume about 50% less energy than traditional buildings for sectors like education and healthcare. Hand's plan seems to be working: revenue is expected to more than double this year.
She is now so successful that her mother has hired a security team who monitor the star 24/7.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Buyers and Sellers
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
12. 最有希望的迹象。有段时间，你会觉得现状已经改善了，人们可以公开大声谈及业内的歧视现象。维奥拉·戴维斯(Viola Davis)出来说话，詹妮弗·劳伦斯(Jennifer Lawrence)公开谈起，自己比片中的合作男星片酬少。“我不想被视为‘难搞’或者‘被宠坏了’，”她在简报《伦尼》(Lenny)中为许多人发言，其中包括许多薪酬更低的人们。
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
The Disaster Artist is part buddy movie, part show-business fable, and part behind-the-scenes DVD featurette.
Anti-HIV drug repurposing against SARS-CoV-2
Scott Brooks gets leeway as he learns his roster, and injuries continue to play too big a role. But I just can't fathom why this team is so much worse than the playoff team from a couple years back. The other piece is that it's unlikely the Wizards can conceivably be bad enough to get a top-five pick.
Length-scale dependence of protein hydration-shell density
Those born after 1995 tend to make more varied choices and are likely to combine work with their hobbies.
New Year's greetings and best wishes!
The state-sponsored purchasing managers' index fell from 50.8 in October to 50.3 in November, the lowest reading since March. Any level above 50 indicates expansion.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
There has also always been a certain fluidity to this concept of whiteness. Irish and Italian immigrants to the United States, and Jews in Britain, were once seen as separate from the white national majority, and are now generally considered part of it, benefiting from racial privilege. At the same time, Jews’ white skin did not protect them from being cast as outsiders by some of Mr. Trump’s supporters who have circulated anti-Semitic memes on social media.
“We weren’t looking to throw the bums out, as they might say about an election. We were just really impressed with a flood of new powertrains, ” says Drew Winter, WardsAuto World Editor-in-Chief. “What was great yesterday might be less impressive tomorrow because engine technology is changing so rapidly.”
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
Online registration will end on Oct. 24. The exam will be held on Nov. 27 in major Chinese cities.
THE AMERICANS (FX, Jan. 28) Season 3 of this terrific blend of Cold War spy thriller and family drama begins with Washington’s K.G.B. contingent feeling the weight of the Soviet war in Afghanistan. Frank Langella joins the cast as the new handler for the show’s husband-and-wife agents, replacing Margo Martindale’s Claudia. (Making its premiere eight days later: NBC’s “Allegiance,” about Russian spies embedded in the United States. Huh.)
About this collection
“New Yorkers have been waking up and realizing this long period of prosperity has wreaked a little bit of havoc on things that we think of as classic New York,” said Simeon Bankoff, the executive director of the Historic Districts Council, noting that 2015 will mark the 50th anniversary of the New York City landmarks preservation law. “Things we always thought were going to be there are just closing left and right.”