Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
As you graduate, my friends, remember what lies ahead of you is a world overflowing with beauty and potential; not just in the form of office corridors or Wall Street but a real, throbbing world, full of many mysteries and heady experiences. A number of us miss this simple truth.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
For: Oldman's seemingly effortless embodiment of the wartime leader has won almost universal
Jackdaw Research的简?道森(Jan Dawson)表示，最近几个月“他表现得更加意气风发和充满自信”。
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
There was no immediate word from the Romney camp on the reported results。
You're the best present I ever received.你是我所收到的最好的礼物。
Hailed as one of the greatest films of all time, Taxi Driver tells the story of a depressed ex-Marine who attempts to assassinate a senator after being rejected by a woman he admires. While the titular taxi driver, Travis Bickle, lives a chaotic life filled with drug dealers and prostitutes, his story was never meant to be an unrealistic fantasy. Rather, it meant to expose the very real warning signs of a would-be gunman.
Trends and targets in antiviral phototherapy
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
The US box office, which includes totals from Canada, hit $11.1 billion, an 8 percent increase year-over-year, and was credited to several smash hits, including Jurassic World ($652 million domestically), Avengers: Age of Ultron ($459 million) and Inside Out ($356 million).
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
We will deepen rural reform.
There are always one or two coworkers in the office that most people can't stand. But if you don't like most of your coworkers, chances are your days aren't very enjoyable because you have to work with them day in and day out. If you can't stand most of your coworkers, it's time to think about finding a company whose employees you mesh with better.
ACE2 as a potential therapeutic target for pandemic COVID-19
But some people might just remember the mustaches.
Diagnostic technologies for COVID-19: a review
Though Hand was British Petroleum's SVP of Global Brand, Marketing and Innovation, for several years, she's on a much more environmentally friendly mission today. Project Frog aims to revamp the construction industry with simple-to-build spaces (they takes days, rather than months to construct) that consume about 50% less energy than traditional buildings for sectors like education and healthcare. Hand's plan seems to be working: revenue is expected to more than double this year.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Song “Fire In The Winter”(Kenji Wu and Dream Chorus)
Yet if “Mad Men” showed us anything (besides how cool a skinny suit could look, and that wide ties really were not a good men’s wear moment), it is that the decade chronicled was a complicated, often unhappy, occasionally destructive time.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
8. Sturgill Simpson “Metamodern Sounds in Country Music” (High Top Mountain) A throwback progressive hunkered down with a whip-smart band: country music has seen this before. But on his breakthrough second album, Sturgill Simpson made it a pliable trademark, grounded at every turn by his winning, seen-it-all baritone.
3. Dan Weiss “Fourteen” (Pi Recordings) There’s so much in “Fourteen,” the album-length composition by the drummer Dan Weiss: meticulous chamber maneuvers; avant-garde yowling; wordless vocals of new-music and northern Indian pedigree. More impressive than the expansive frame of reference is the fact that Mr. Weiss, marshaling about a dozen of his peers, spins it all into a flowing fabric.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
The block chain has such rich potential that there is an initiative underway to create additional “side chains,” though there is controversy around that idea. “We don’t really want to mess with the main block chain right now,” says Adam Ludwin, CEO of Chain, a block chain API that makes it easier to create bitcoin applications. “It works, we don’t want to break it.”
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Belgium, for example, has less than a tenth of the population of Russia, its rival in the group stage, but is regarded as a far greater threat. And then there is Uruguay, which despite fewer than 4 million citizens -- barely a sixth of the population of greater S?o Paulo -- is one of the teams Brazil would least like to meet on its way to the final. How is this so?
Antiviral drug discovery: broad-spectrum drugs from nature
Influenza neuraminidase: A druggable target for natural products
Yes. There are plenty of positives: earnings, economic growth, and US tax cuts. But they are already known. Stocks look ridiculously expensive by historical standards, but that tells us nothing about short-term moves. Ultimately, it comes down to liquidity, which has driven markets since they emerged from the crisis in 2009. If all goes according to plan, central banks will be decreasing their balance sheets, and removing liquidity, by the end of 2018. If they go through with this, the odds are that the S&P will stall. But even a tiny tremor could make the bankers blink. Expect the momentum to continue.
That possibility was backed up by a list of top-tier cities the statistics bureau began tracking recently
Companies do have black lists. It's not written down anywhere but it's a list of people they'd be happy to get rid of if the opportunity arises. If you feel invisible, if you're getting bad assignments, if your boss is ignoring you, or if they move your office, you're probably on it.
As the calendar flips to December it’s not too early to think about the inevitability of tanking. Who should do it, who should wait, and who shouldn’t ever consider it. Flanns and Zillz discuss.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The role of biosensors in the detection of emerging infectious diseases
adj. 故意的，有意的；打算中的 n. 已订婚者 v.
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Consumer Electronics Show
“We will see a lot of headlines about [emerging market export growth] picking up in the first half of 2017,” says Bhanu Baweja, head of EM cross asset strategy at UBS, who believes EM exports will show year-on-year growth of between 8 and 13 per cent in dollar terms in the first quarter of this year, “a complete postcode away” from the negative numbers currently being reported.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
D'Aloisio himself strives to maintain a bubble of normalcy. He dates the same girl he did before the whirlwind hit. And though he's stopped attending school-he's too busy to sit in class while overseeing Summly's development-he still gets his work from his teachers and meets with them regularly. He cherishes the fact that his circle of friends knows little of his life as a budding industrialist. When I met him, he was about to head to Greece for a weeklong vacation with a pack of high school pals.
However, five Beijing-based travel agents said they were still selling South Korea tours for March, as was China’s largest online travel company Ctrip. Representatives at the top three state-owned airline carriers in China told Bloomberg they had not received instructions to halt ticket sales to the country.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Inhibition of SARS coronavirus helicase by bismuth complexes
Western states dominate the best states for projected job growth. Only two, Florida and Georgia, of the top 10 are located east of the Mississippi River. Rounding out the top five are Colorado (2.6% annual projected growth), North Dakota (2.5%) and Florida (2.5%).
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
“Insead enormously boosted our intercultural experience,” said one alumni survey respondent from Switzerland. “It is a place to learn global culture better than anywhere else.”
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Martin Ford, author of The Rise of the Robots , received the 30,000 Financial Times and McKinsey Business Book of the Year Award at a ceremony in New York on Tuesday.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Erle Spratt, who manages M&G’s Asia property fund, an open-ended investment vehicle, says it is risky to invest directly because assets are not easy to find and price. “It is a very difficult market to buy assets in for investors like us, because developers have very substantial holdings and they tend not to sell,” he says.
Six regions recorded GDP growth less than 7 percent, with China's north-eastern rust belt Liaoning province at the bottom with negative growth.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
We will make continued progress in building a Healthy China.
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Developer activity is also at a fever pitch. According to the contributor graph at GitHub, the total number of contributions to bitcoin’s master code in November was the highest it had been since spring 2012. Bitcoin is also the 31st “most forked repository” on GitHub—”forks” are basically proposed or in-progress alterations to core code—out of more than 900,000. In other words, for developers, bitcoin is trending. The number of open jobs currently posted at bitcoin companies also underscores developer interest: it’s at 105, which is close to the all-time high in September of 137, according to Bitcoin Pulse, which monitors such trends.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
So take a look. I sincerely hope you enjoy reading them as much as I liked selecting and editing them.
The memes were shared as part of a private Facebook chat where admitted students in the class of 2021 shared edgy jokes as part of a "just-because-we-got-into-Harvard-doesn't-mean-we-can't-have-fun kind of thing", an admitted student told the Harvard Crimson.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Perhaps in response, at the start of 2017, China's media regulator quietly began including service fees charged by online ticketing companies when reporting box-office figures.
UK schools account for more than a third of all graduates from the top 50 pre-experience programmes and not only attracted nearly half of all female students but also almost half of all international students. Indeed, 94 per cent of students enrolled in a UK MiF pre-experience programme in 2014 were from overseas. About 85 per cent of these students were from outside the European Economic Area, including 55 per cent of the overall number from mainland China.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
And, thanks to Artnet and other databases that list auction results, wealthy people who buy art have become all too aware of how hard it is to make a profit on old masters.
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
At school, even in kindergarten, you teach us to behave in the world. You teach us: not to fight with others, to respect others, to clean up our mess, not to hurt other creatures, to share - not be greedy. 在学校，甚至在幼稚园，你们大人教我们如何处世，你们告诉我们不要打架，要尊重对方。找出答案，解决矛盾。去分享，而不是贪婪。
The surviving cat, since named Trooper, has recovered and found a new home.
You see all kinds of grisly, hairy characters on the Tube but few commuters would've expected to see a pack of pandas on the platform.
10.Firefly was Inspired by Gettysburg
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Spotify, the music streaming service, plans to list existing private shares directly on the New York Stock Exchange as soon as the fourth quarter rather than doing a formal IPO, while other large, well-known tech companies for now were seen as more likely prospects for 2018, bankers said.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
But if the U.S. can avert that Washington-made crisis, the outlook for workers finding jobs is actually looking pretty good for next year. For one thing, the damage of superstorm Sandy will have to be repaired, meaning jobs in construction and retail. Businesses, meanwhile, which have held off investing and hiring because of uncertainty over the fiscal outlook, might finally open their wallets. That means more jobs, too.[qh]
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
These contraptions, including a nano-sized car, are so small that they’re invisible to the human eye.
A modular microarray imaging system for highly specific COVID-19 antibody testing
While the WeChat use of the "post-90s" generation has slightly decreased, from 94.1 percent to 86.6 percent.
While newcomer to the list Ariel Foxman, who was appointed managing editor at Time Inc.’s In Style in September 2008, isn’t a regular on a television show as of yet, his fashion director Hal Rubenstein is now a judge onLifetime’s Blush: The Search for the Next Great Make-up Artist. And Foxman’s publication led the way in number of advertising pages, boasting over 1,000 during the first half of 2009.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
At a Senate committee hearing on extrajudicial executions in the Philippines, Ronald Dela Rosa said 712 people had been killed in police anti-narcotics operations since July 1, the day after Mr Duterte assumed the presidency, while 1,067 deaths were being investigated as drug-related vigilante killings.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
The fastest-rising sector is apparel, driven by Nike in sportswear as people pay more attention to health and fitness, and Zara, whose fast fashion is becoming increasingly popular in China.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
We will accelerate the development of emerging industries.
1.It wasn’t me! – Because some things just aren’t worth taking credit for。
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
This sign varies from company to company. You must keep in mind that we are in a recession and if sales are down but the company isn't in jeopardy, this sign may not apply to you. However, if business is down to the point where it looks like the company is going to go under, start looking for a new job NOW! (See also: 20 Signs that a Pink Slip is Coming)
Under the Skin is just so visually free and uninhibited that there is an intense dark, destructive sexiness in everything about it – quite apart from the hilarious, bizarre, mesmeric eroticism of the film itself. It is a work of subcutaneous potency. It gets under your skin.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
"If all these train tickets were lined up, they would circle the earth 7 times," said Zhu Jiansheng, deputy director of the Institute of Computing Technologies with the Chinese Academy of Railway Sciences, where the ticketing system was developed.
A facile assay for rapid detection of COVID-19 antibodies
年度故事将是纽约对911主谋穆罕默德(Khalid Sheikh Mohammed)的审判。
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
5. What are my core values? What is important to you as an individual? Is it family, health, spirituality, work, etc.? Make sure that you are living in alignment with what matters most to you.
That was a less marked jump than the 3 percentage point rise from August to September, however, suggesting recent curbs to property purchases may be having some effect.
上述消息源还称，苹果将在明年10月发布一款12.9英寸的平板电脑，“目标消费群是北美的教育市场（和）……生产商是广达电脑（Quanta Computer）”。有报道称，三星也在研发尺寸在12至13英寸之间的平板电脑，而现在看来，“这些大尺寸平板电脑将极大地影响超极本需求”几乎是板上钉钉的事了。新款“iPad Max”，搭载整合了键盘和电池的新款外壳之后，实际上就是一台笔记本电脑，很有可能在高中生和大学生之中成为主流产品——这一人群需要比现有iPad和iPad Mini产品更好的内容创造工具。
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
5.Celebrity Mocks Mao
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
I formerly had an Android device (even though I have had a MacBook since 2009 – weird, I know). After switching this summer, I quickly realized the power of iPhone “Reminders.” Each time a reminder is due, your iPhone buzzes and displays a pop-up. You can snooze it or mark as completed. In addition, you can set up recurring reminders, which are perfect for remembering to mail estimated quarterly tax payments, renewing subscriptions, running payroll and other things you tend to forget.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Andy Murray's US Open victory and Olympic gold medal helped him to become the most searched-for British Olympian.
2) I often talk to strangers 0 1 2 3 4
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
The details of her character are being kept under wraps.
Anti-HIV drug repurposing against SARS-CoV-2
8. Ford Motor
Rios is no stranger to hard work. She moved to the U.S. from El Salvador when she was a child. She graduated at the top of her high school class and raised a family while putting herself through college. She was not intimidated when she started Nation Waste Inc. At just 22, months after graduating from the University of Houston, she took out loans and purchased two trucks, jumping into the male-dominated waste-removal industry. Today, her Houston-based company has 24 full-time employees. "It is pretty amazing when I look back and see, I started as a little girl entering the United States with my parents and now I am truly living the American dream," says Rios.
Length-scale dependence of protein hydration-shell density
"No one really knows how (end times) would look and how God would bring it about," Cox said.
White anxiety has fueled this year’s political tumult in the West: Britain’s surprising vote to exit the European Union, Donald J. Trump’s unexpected capture of the Republican presidential nomination in the United States, the rise of right-wing nationalism in Norway, Hungary, Austria and Greece.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Roth, 60, is a professor at Harvard University in Boston. Shapley, 89, is a professor emeritus at University of California Los Angeles.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
西门子(Siemens)去年破纪录了，通过将医疗部更名为Healthineers一举斩获两项大奖。该公司不仅因为将两个单词生拼硬造出另一个无比蹩脚的新词从而荣获“马丁?卢克斯奖”(Martin Lukes prize)，同时还凭借现场视频中一位倾情演唱的CEO和身着氨纶紧身衣卖力献舞的员工们，摘得史上最尴尬企业歌曲的金牌。
With executive compensation in the U.S. rising and the income gap only getting bigger, it's refreshing to see a CEO who cares about more than his own paycheck. Lenovo(LNVGF) Chief Executive Yang Yuanqing announced in September for the second year in a row that he would share at least $3 million of his bonus with roughly 10,000 of his workers. The generous decision was a product of the personal computer maker's record sales that year. The average worker payout is equal to roughly a month's pay for the typical city worker in China, according to Bloomberg News.
About this collection
It was the spring of hope, it was the winter of despair…